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Day

June 8, 2022
Original Investigation

Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial

Abstract Full Text
JAMA Dermatol. Published online June 8, 2022. doi:10.1001/jamadermatol.2022.1891

This randomized clinical trial evaluates the clinical efficacy of topical tretinoin precursors and tretinoin in treating moderate to severe facial photodamage and identifies potential biomarkers that correlate with clinical efficacy.

Review

Patient-Relevant Outcomes in Psoriasis: A Systematic Review

Abstract Full Text
has active quiz
JAMA Dermatol. Published online June 8, 2022. doi:10.1001/jamadermatol.2022.1756

This systematic review generates a comprehensive overview of all outcomes relevant in the management of psoriasis as defined by patients.

JAMA Dermatology Clinicopathological Challenge

Painful Mucosal Ulcerations in a Patient With HIV

Abstract Full Text
has active quiz
JAMA Dermatol. Published online June 8, 2022. doi:10.1001/jamadermatol.2022.2034

A man in his 40s with HIV presented to the emergency department with nausea, abdominal pain, bloody stools, odynophagia, and recurrent mucosal ulcers; he was found to have pancytopenia and septic shock. What is your diagnosis?

An Asymptomatic Verrucous Plaque on the Right Temple of an Adolescent Girl

Abstract Full Text
has active quiz
JAMA Dermatol. Published online June 8, 2022. doi:10.1001/jamadermatol.2022.2056

An adolescent girl presented with an asymptomatic slightly reddish verrucous plaque on the right temple; the skin lesion was nail sized when first noticed 1½ years ago, then gradually developed over the previous 8 months. What is your diagnosis?

Research Letter

Incidence of and Risk Factors for Keratinocyte Carcinoma After Pediatric Solid Organ Transplant

Abstract Full Text
JAMA Dermatol. Published online June 8, 2022. doi:10.1001/jamadermatol.2022.1960

This cohort study identifies the risk factors for and the incidence of keratinocyte carcinoma among patients who underwent solid organ transplant during childhood compared with the general population in Ontario, Canada.

Observation

Use of Dupilumab and Eosinophil Targeted Therapy in Treating Angiolymphoid Hyperplasia With Eosinophilia

Abstract Full Text
JAMA Dermatol. Published online June 8, 2022. doi:10.1001/jamadermatol.2022.1969

This case report describes a 68-year-old woman who presented with 2 years of fixed diffuse dermal nodules that began to develop on the right neck.

June 1, 2022
Original Investigation

Effect of Reflectance Confocal Microscopy for Suspect Lesions on Diagnostic Accuracy in Melanoma: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Dermatol. Published online June 1, 2022. doi:10.1001/jamadermatol.2022.1570

This randomized clinical trial tests the hypothesis that reflectance confocal microscopy reduces unnecessary lesion excision by more than 30% and identifies all melanoma lesions larger than 0.5 mm at baseline.

Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial

Abstract Full Text
JAMA Dermatol. Published online June 1, 2022. doi:10.1001/jamadermatol.2022.1736

This randomized clinical trial assesses if epigallocatechin-3-gallate solution reduces the incidence of radiation-induced dermatitis in patients undergoing radiotherapy after breast cancer surgery.

Circulating Brodalumab Levels and Therapy Outcomes in Patients With Psoriasis Treated With Brodalumab: A Case Series

Abstract Full Text
JAMA Dermatol. Published online June 1, 2022. doi:10.1001/jamadermatol.2022.1863

This case series study assesses measured trough levels of circulating brodalumab and in patients who experienced failure with anti–interleukin 17 α therapy and whether brodalumab levels are associated with clinical response.

Brief Report

Assessment of Delayed Large Local Reactions After the First Dose of the SARS-CoV-2 mRNA-1273 Vaccine in Japan

Abstract Full Text
free access
JAMA Dermatol. Published online June 1, 2022. doi:10.1001/jamadermatol.2022.2088

This cross-sectional study assesses the association of the first dose of the SARS-CoV-2 mRNA-1273 vaccine with delayed large local reactions by sex and age in Japan.

Association of Tumor Characteristics With Insurance Type Among Patients Undergoing Mohs Micrographic Surgery for Nonmelanoma Skin Cancer

Abstract Full Text
JAMA Dermatol. Published online June 1, 2022. doi:10.1001/jamadermatol.2022.1802

This cohort study assesses whether tumor and treatment characteristics differ based on insurance type among patients with nonmelanoma skin cancer (NMSC) undergoing Mohs micrographic surgery.

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