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2022
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June 6, 2022
Viewpoint

Disclosing Alzheimer Disease Biomarker Results to Research Participants

Joshua D. Grill, PhD; Jason Karlawish, MD
Abstract Full Text
JAMA Neurol. Published online June 6, 2022. doi:10.1001/jamaneurol.2022.1307

This Viewpoint discusses issues surrounding the release of biomarker measures by research studies to their participants.

Original Investigation

Association of Aortic Stiffness and Pressure Pulsatility With Global Amyloid-β and Regional Tau Burden Among Framingham Heart Study Participants Without Dementia

Leroy L. Cooper, PhD, MPH; Adrienne O’Donnell, BA; Alexa S. Beiser, PhD; et al.
Abstract Full Text
JAMA Neurol. Published online June 6, 2022. doi:10.1001/jamaneurol.2022.1261

This cross-sectional study evaluates the association of aortic stiffness and pressure pulsatility with global amyloid-β and regional tau burden among middle-aged and older Framingham Heart Study Third Generation participants without dementia.

Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months: A Secondary Analysis of the RESCUEicp Randomized Clinical Trial

Angelos G. Kolias, MD, PhD; Hadie Adams, MD; Ivan S. Timofeev, PhD; et al.
Abstract Full Text
JAMA Neurol. Published online June 6, 2022. doi:10.1001/jamaneurol.2022.1070

This randomized clinical trial uses Extended Glasgow Outcome Scale scores to evaluate 24-month outcomes for patients with traumatic intracranial hypertension who received a decompressive craniectomy vs standard medical treatment.

JAMA Neurology Clinical Challenge

Bilateral Complete Ophthalmoplegia in a 50-Year-Old Man

Nitika Arora, MBBS; Jacqueline Leavitt, MD; John J. Chen, MD, PhD
Abstract Full Text
has active quiz
JAMA Neurol. Published online June 6, 2022. doi:10.1001/jamaneurol.2022.1320

A 50-year-old man had ophthalmoplegia that developed immediately after robotic cystectomy for small cell cancer of the bladder. What is your diagnosis?

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