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June 2022, Vol 182, No. 6, Pages 583-691

Viewpoint

Medicare Coverage of Vaccines—A Work in Progress

Francis J. Crosson, MD
Abstract Full Text
JAMA Intern Med. 2022;182(6):585-586. doi:10.1001/jamainternmed.2022.0624

This Viewpoint explains issues with the current system for coverage of preventive vaccines under Medicare and includes recommendations for reforming this coverage system.

Original Investigation

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial

Ajay K. Singh, MBBS; Borut Cizman, MD; Kevin Carroll, PhD, CStat, CSci; et al.
Abstract Full Text
open access
JAMA Intern Med. 2022;182(6):592-602. doi:10.1001/jamainternmed.2022.0605

This randomized clinical trial investigates whether daprodustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, is safe and noninferior compared with darbepoetin alfa in treating anemia of chronic kidney disease in incident dialysis patients.

Hospital-Administered Cancer Therapy Prices for Patients With Private Health Insurance

Roy Xiao, MD, MS; Joseph S. Ross, MD, MHS; Cary P. Gross, MD; et al.
Abstract Full Text
JAMA Intern Med. 2022;182(6):603-611. doi:10.1001/jamainternmed.2022.1022

This cross-sectional study examines the extent and visibility of markups for drugs used in cancer therapy.

Assessment of Awake Prone Positioning in Hospitalized Adults With COVID-19: A Nonrandomized Controlled Trial

Edward Tang Qian, MD; Cheryl L. Gatto, PhD; Olga Amusina, DNP; et al.
Abstract Full Text
open access has active quiz
JAMA Intern Med. 2022;182(6):612-621. doi:10.1001/jamainternmed.2022.1070

This nonrandomized controlled trial uses a modified World Health Organization ordinal scale to assess whether awake prone positioning was associated with improved clinical outcomes among patients with COVID-19–related hypoxemia who require supplemental oxygen but have not received invasive mechanical ventilation.

Stress-Related Disorders of Family Members of Patients Admitted to the Intensive Care Unit With COVID-19

Timothy Amass, MD, ScM; Lauren Jodi Van Scoy, MD; May Hua, MD, MS; et al.
Abstract Full Text
free access has active quiz
JAMA Intern Med. 2022;182(6):624-633. doi:10.1001/jamainternmed.2022.1118

This cohort study examines the prevalence of stress-related disorders in family members of patients admitted to the intensive care unit with COVID-19.

Less Is More

Evaluation of the Incremental Value of a Coronary Artery Calcium Score Beyond Traditional Cardiovascular Risk Assessment: A Systematic Review and Meta-analysis

Katy J. L. Bell, PhD; Sam White, MD; Omar Hassan, MD; et al.
Abstract Full Text
has audio
JAMA Intern Med. 2022;182(6):634-642. doi:10.1001/jamainternmed.2022.1262

This systematic review and meta-analysis evaluates the incremental value of coronary artery calcium scans beyond traditional cardiovascular risk assessment.

Remote Monitoring and Behavioral Economics in Managing Heart Failure in Patients Discharged From the Hospital: A Randomized Clinical Trial

David A. Asch, MD; Andrea B. Troxel, ScD; Lee R. Goldberg, MD, MPH; et al.
Abstract Full Text
open access
JAMA Intern Med. 2022;182(6):643-649. doi:10.1001/jamainternmed.2022.1383

This randomized clinical trial examines the use of remote monitoring of weight and adherence to diuretic therapy in patients with heart failure after hospital discharge.

Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults: An Ancillary Analysis of the LIFE Study Randomized Clinical Trial

Michael G. Shlipak, MD, MPH; Anoop Sheshadri, MD, MAS; Fang-Chi Hsu, PhD; et al.
Abstract Full Text
JAMA Intern Med. 2022;182(6):650-659. doi:10.1001/jamainternmed.2022.1449

This ancillary analysis of the Lifestyle Interventions and Independence For Elders Study evaluates whether a moderate-intensity exercise intervention can affect the estimated glomerular filtration rate per cystatin C change in older adults.

Less Is More

Time to Clinical Benefit of Intensive Blood Pressure Lowering in Patients 60 Years and Older With Hypertension: A Secondary Analysis of Randomized Clinical Trials

Tao Chen, PhD; Fang Shao, PhD; Kangyu Chen, PhD; et al.
Abstract Full Text
open access
JAMA Intern Med. 2022;182(6):660-667. doi:10.1001/jamainternmed.2022.1657

This secondary analysis of randomized clinical trials estimates the time needed to potentially derive clinical benefit from intensive blood pressure treatment in patients 60 years and older.

Editorial

Whom to Treat for Primary Prevention of Atherosclerotic Cardiovascular Disease: The Aspirin Dilemma

Samia Mora, MD, MHS; Chrisandra L. Shufelt, MD, MS; JoAnn E. Manson, MD, DrPH
Abstract Full Text
has audio
JAMA Intern Med. 2022;182(6):587-589. doi:10.1001/jamainternmed.2022.1365

Less Is More

Addition of Coronary Artery Calcium Scores to Primary Prevention Risk Estimation Models—Primum Non Nocere

Robert J. Gallo, MD; David L. Brown, MD
Abstract Full Text
has audio
JAMA Intern Med. 2022;182(6):590-591. doi:10.1001/jamainternmed.2022.1258
Invited Commentary

Prone Positioning for Nonintubated Patients With COVID-19—Potential Dangers of Extrapolation and Intermediate Outcome Variables

Peter D. Sottile, MD; Richard K. Albert, MD; Marc Moss, MD
Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):622-623. doi:10.1001/jamainternmed.2022.1086
Research Letter

Assessment of Provision of COVID-19 Vaccination in Dialysis Clinics and Patient Vaccination Coverage

Priti R. Patel, MD, MPH; Lauren J. Tanz, ScD, MSPH; Emel Hamilton, DrMed, MSN/INF, CNN; et al.
Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):676-678. doi:10.1001/jamainternmed.2022.0627

This quality improvement study assesses COVID-19 vaccination in dialysis clinics, vaccination coverage, and disparities from December 1, 2020, to June 13, 2021.

COVID-19 Vaccine Uptake and Intentions Following US Food and Drug Administration Approval of the Pfizer-BioNTech COVID-19 Vaccine

Aaron M. Scherer, PhD; Andrew M. Parker, PhD; Courtney A. Gidengil, MD, MPH; et al.
Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):678-680. doi:10.1001/jamainternmed.2022.0761

This survey study assesses vaccination intentions of unvaccinated US adults in response to full US Food and Drug Administration (FDA) approval of the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine and any demographic characteristics associated with those intentions.

Association of Medical Assistant–Supported Virtual Rooming With Successful Video Visit Connections

Tracy A. Lieu, MD, MPH; E. Margaret Warton, MPH; Christine Levan, MD; et al.
Abstract Full Text
JAMA Intern Med. 2022;182(6):680-682. doi:10.1001/jamainternmed.2022.1032

This quality improvement study assesses the success of medical assistant–supported virtual rooming for physician video visits among patients in Kaiser Permanente Northern California.

How Traditional Advance Directives Undermine Advance Care Planning: If You Have It in Writing, You Do Not Have to Worry About It

Catherine L. Auriemma, MD, MS; Helen O’Donnell, BS; Tamar Klaiman, PhD, MPH; et al.
Abstract Full Text
JAMA Intern Med. 2022;182(6):682-684. doi:10.1001/jamainternmed.2022.1180

This research explores the perspectives of seriously ill patients on the completion of documentation and the implementation of advance directives and advance care planning.

Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population

Helene Kildegaard, MD; Louise Ladebo, MScPharm, PhD; Jacob Harbo Andersen, MSc; et al.
Abstract Full Text
free access has active quiz
JAMA Intern Med. 2022;182(6):684-686. doi:10.1001/jamainternmed.2022.1222

This cohort study used data from Danish registers to assess whether recipients of mRNA COVID-19 vaccines had a higher risk of appendicitis after receiving the shot compared with individuals who did not receive the vaccine.

Challenges in Clinical Electrocardiography

Acute Myocardial Infarction or Not?

Chuan-Hai Zhang, MD; Ting-Ting Li, MD; Xiaohong Chen, MD
Abstract Full Text
has active quiz
JAMA Intern Med. 2022;182(6):668-669. doi:10.1001/jamainternmed.2022.0519

This case report describes a patient in their 70s with no history of chronic disease or acute infection who presented to the emergency department with acute chest pain that had lasted 3 hours.

An Important Cause of Wide Complex Tachycardia

Aravind G. Kalluri, MD; Alan Sugrue, MD; David S. Frankel, MD
Abstract Full Text
has active quiz
JAMA Intern Med. 2022;182(6):670-671. doi:10.1001/jamainternmed.2022.0524

This case report describes a man in his 60s who was admitted to the intensive care unit with necrotizing pancreatitis and biliary stenosis complicated by pneumonia, hypoxic respiratory failure, and convulsive seizures.

Malignant Anterior ST-Segment Elevation

Luca Bergamaschi, MD; Alberto Foà, MD; Carmine Pizzi, MD
Abstract Full Text
has active quiz
JAMA Intern Med. 2022;182(6):672-673. doi:10.1001/jamainternmed.2022.0661

This case report presents the electrocardiogram findings of a patient in their 70s with hypertension and previous high-grade bladder urothelial carcinoma that was treated with radical cystectomy.

Ominous Electrocardiographic Abnormalities in a Patient With Hepatocellular Carcinoma

Yu Xu, MD; Lili Hong, MD; Tong Liu, MD, PhD
Abstract Full Text
has active quiz
JAMA Intern Med. 2022;182(6):674-675. doi:10.1001/jamainternmed.2022.1226

This case report describes the electrocardiogram findings of a patient with 1 week of progressive weakness, myalgia, dyspnea, and ptosis.

JAMA Internal Medicine Patient Page

What Can At-home Genetic Tests Tell Me About My Health?

Anna L. Parks, MD; Michael A. Incze, MD, MSEd
Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):691. doi:10.1001/jamainternmed.2022.0529

This JAMA Internal Medicine Patient Page describes the use and accuracy of, as well as harms and concerns associated with, at-home genetic tests.

Comment & Response

Management of Chronic Low Back Pain

Thiru M. Annaswamy, MD, MA; Michael Hatzakis Jr, MD; Andre Panagos, MD
Abstract Full Text
JAMA Intern Med. 2022;182(6):686-687. doi:10.1001/jamainternmed.2022.0742

Management of Chronic Low Back Pain

Aaron Conger, DO; Belinda Duszynski, BS; Zachary L. McCormick, MD
Abstract Full Text
JAMA Intern Med. 2022;182(6):687. doi:10.1001/jamainternmed.2022.0745

Management of Chronic Low Back Pain—Reply

Kenneth R. Cohen, MD
Abstract Full Text
JAMA Intern Med. 2022;182(6):687-688. doi:10.1001/jamainternmed.2022.0748

Major Concerns Remain With Gestational Weight Gain and Pregnancy Burden

Minjing Luo, MD; Yuting Feng, MD; Yutong Fei, PhD
Abstract Full Text
JAMA Intern Med. 2022;182(6):688-689. doi:10.1001/jamainternmed.2022.1255

Major Concerns Remain With Gestational Weight Gain and Pregnancy Burden—Reply

Cheryce L. Harrison, PhD; Joanne Enticott, PhD; Helena J. Teede, PhD, MBBS
Abstract Full Text
JAMA Intern Med. 2022;182(6):689. doi:10.1001/jamainternmed.2022.1259

Clarification of Conflict of Interest Disclosures

Beth D. Darnall, PhD
Abstract Full Text
JAMA Intern Med. 2022;182(6):689-690. doi:10.1001/jamainternmed.2022.0809
Correction

Clarification of Conflict of Interest Disclosures

Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):690. doi:10.1001/jamainternmed.2022.0812

Clarification of Conflict of Interest Disclosures

Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):690. doi:10.1001/jamainternmed.2022.0813

Clarification of Conflict of Interest Disclosures

Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):690. doi:10.1001/jamainternmed.2022.0814

Additional Information About Source of Study Drug and Typographical Error in Supplement

Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):690. doi:10.1001/jamainternmed.2022.1523
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
free access
JAMA Intern Med. 2022;182(6):583. doi:10.1001/jamainternmed.2021.6082

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